Exploring the Antimicrobial Potential of Marine-Derived Actinobacteria: Metabolomics Analysis and Identification of Novel Bioactive Metabolites

Abstract

Although it cannot be prevented, antimicrobial resistance is a serious public health concern that contributed to around 5 million deaths in 2019. It can be managed by looking for new antibacterial substances. Because their secondary metabolites include a variety of biological actions, such as antibacterial, antifungal, antiviral, and anticancer properties, marine actinobacteria are a valuable resource for biotechnological study and the exploration of novel metabolites.

Aim:

The purpose of this work is to do a thorough metabolomics analysis of the bioactive metabolites of marine-derived Actinobacteria and assess their antibacterial efficacy. Finding new antimicrobial agents and clarifying the connection between certain metabolites and antimicrobial efficacy are the goals of the study.

Methods:

A study of previous research on Actinobacteria crude extract was carried out, and the agar well diffusion method was used to assess the crude extract's antibacterial activity. Gas chromatography-mass spectrometry (GC-MS) was used to identify the components of metabolites. Results:Marine Actinobacteria strains with strong antibacterial activity were found in the study, especially against bacteria that are resistant to multiple drugs. Bioactive metabolites that are strongly associated with antimicrobial properties were identified by metabolomics profiling. conclusion:marine Actinobacteria offer interesting metabolites for drug development; more characterisation of Streptomyces metabolites could result in the development of novel medications for a number of illnesses.